Semitelechelic HPMA copolymers functionalized with triphenylphosphonium as drug carriers for membrane transduction and mitochondrial localization
J Callahan, J Kopeček - Biomacromolecules, 2006 - ACS Publications
Semitelechelic HPMA (N-(2-hydroxypropyl) methacrylamide) copolymers possessing a
single terminal lipophilic triphenylphosphonium (TPP) cation and fluorescent labels were
synthesized to determine how the attached cation affected cellular uptake and intracellular
trafficking. In vitro mitochondrial uptake fluorescence quenching assays using isolated
mouse liver mitochondria indicated that only lower molecular weight (< 5 kDa) BODIPY FL-
labeled TPP-semitelechelic HPMA copolymers exhibited significant organelle localization or …
single terminal lipophilic triphenylphosphonium (TPP) cation and fluorescent labels were
synthesized to determine how the attached cation affected cellular uptake and intracellular
trafficking. In vitro mitochondrial uptake fluorescence quenching assays using isolated
mouse liver mitochondria indicated that only lower molecular weight (< 5 kDa) BODIPY FL-
labeled TPP-semitelechelic HPMA copolymers exhibited significant organelle localization or …
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